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apalutamide will lower the level or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medications which can be CYP3A4 substrates can lead to reduced publicity to these prescription drugs.Antihistamines: concomitant administrati